I don't have the UR-22, though from all I've heard so far it is a very good sound device. I therefore cannot answer your question with 100% certainty. I can tell you however that I can route Windows' default audio to my Zoom R24 which is also an ASIO-capable USB2.0 device. So if we are talking about Windows and you are running at least Windows 7, you should be fine.
It should be pretty much the same deal on other systems. I can't speak from experience with regard to Macs, but the sound architecture of Mac OS is actually supposed to be a lot cleaner than that of Windows. On Linux there is also no difference, a sound device is a sound device (usually ALSA is used as hardware driver/backend nowadays). However, I'm pretty sure the Steinberg interface is not an ideal candidate for Linux; at least from what I have read, I would recommend the Focusrite Scarlett for that purpose. On Windows and Mac the UR-22 should perform admirably.
In general there is no difference between a 'soundcard' and 'audio interface'. The former is an older term from ye goode olde days when audio devices literally were extension 'cards' (i.e. ISA, PCI(e) or PCMCIA), while the latter is a bit more generic: since the development of USB (and FireWire), a lot of stuff that used to need special interfaces or extension cards in the computer now comes in form of external boxes. Nowadays PCIe audio cards are only used for special applications in science and engineering (where extremly low latency and jitter values might be really vital).
Last edited by kalessin (27-07-2014 16:55)
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